Répertoire toxicologiqueRépertoire toxicologiqueOccupational AsthmaJack Pepys Workshop on Asthma in the Workplace6th Jack Pepys Workshop on Asthma in the Workplace
Discussion of this session focused on:
Presentations of the theme:
After a review on population-based studies of asthma in the workplace, proposal was made to improve asthma phenotypes and characterization of exposure. Also, ways to examine the impact of low participation and assess representativeness were presented.
In this session, the effect of chronic and acute exposures to molds as well as working in recycling processes were reviewed. The mechanism of this effect is still hypothetical.
In this session there was discussion of advantages and disadvantages of new techniques that may be used in diagnosis of IgE antibody responses to occupational sensitizers to improve sensitivity and specificity of allergy skin tests and in-vitro tests of specific IgE for the diagnosis of occupational allergic airways disease. Purified and recombinant allergens can be used as part of in-vivo test (skin prick tests) or in-vitro assays of specific IgE antibodies. Basophil activation tests, when feasible may be useful when specific IgE antibodies cannot be identified, and nasal secretion tryptase was discussed as a possible “point-of-care” test.
Mechanisms by which allergic responses and asthma may be induced or worsened by these exposures were the focus of this session. Although common in work environments most relevant research on mechanisms on these reactions has come from cellular or animal studies with limited human exposure studies. Recent controlled human exposure studies with diesel exhaust particles may reflect effects in occupational settings.
Some issues presented for discussion included: