WHMIS (N,N-Dimethylacetamide)

Workplace Hazardous Materials Information System

WHMIS 2015 classification - Note to reader

• Flammable liquids - Category 41
• Flash point = 66 °C closed cup (non reported method)

• Acute toxicity - inhalation - Category 32 3

• Serious eye damage/eye irritation - Category 24

• Carcinogenicity - Category 25

• Reproductive toxicity - Category 23 6 7 8
• Toxic to the development

• Specific target organ toxicity - single exposure (narcotic effects) - Category 3 - Narcotic effect7 9

• Specific target organ toxicity - repeated exposure - Category 23 7 9

Danger

Combustible liquid (H227)
Toxic if inhaled (H331)
Causes serious eye irritation (H319)
Suspected of causing cancer (H351)
Suspected of damaging fertility or the unborn child (H361)
May cause drowsinesss or dizziness (H336)
May cause damage to organs through prolonged or repeated exposure (H373)

Ingredient disclosure

References

• ▲1.  Dutch Institute for the Working Environment et Dutch Chemical Industry Association, Chemical safety sheets : working safely with hazardous chemicals. Netherlands : Kluwer Academic Publishers. (1991). [RR-015010]
• ▲2.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
• ▲3.  OECD, «N,N-DIMETHYLACETAMIDE (DMAC) CAS N°:127-19-5.» In: OECD Screening Information Data Set (SIDS) for High Production Volume Chemicals. Paris : UNEP Publications. (2001).   http://www.inchem.org/documents/sids/sids/127-19-5.pdf
• ▲4.  Smyth, H.F. et al., «Range-finding toxicity data : List VI.» American Industrial Hygiene Association Journal. Vol. 23, p. 95-107. (1962). [AP-041987]
• ▲5.  American Conference of Governmental Industrial Hygienists, «Dimethylacetamide.» In: Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. Cincinnati, Ohio : ACGIH. (2018). Publication #0100Doc.   http://www.acgih.org
• ▲6.  ECHA (European Chemicals Agency) , Information on chemicals (REACH)/ECHA chemicals database. Helsinki, Finland.   http://echa.europa.eu/information-on-chemicals/registered-substances
  https://chem.echa.europa.eu/
• ▲7.  France. Institut national de recherche et de sécurité, Fiche toxicologique no 261 : N,N-Diméthylacétamide. Cahiers de notes documentaires. Paris : INRS. (2006). [RE-005509]   http://www.inrs.fr/publications/bdd/fichetox.html
  http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_261
• ▲8.  Okuda, H. et al., «Developmental toxicity induced by inhalation exposure of pregnant rats to N,N-dimethylacetamide.» Journal of occupational health. Vol. 48, no. 3, p. 154-160. (2006).
• ▲9.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org

The [number] refers to the Information SST database of the CNESST Documentation Center.