WHMIS (Chloroform)

Workplace Hazardous Materials Information System

WHMIS 2015 classification - Note to reader

• Acute toxicity - oral - Category 41 2 3

• Acute toxicity - inhalation - Category 31 4

• Skin corrosion/irritation - Category 25 6

• Serious eye damage/eye irritation - Category 25 6

• Carcinogenicity - Category 27

• Reproductive toxicity - Category 22 8 9 10 11 12
• Toxic to the development

• Specific target organ toxicity - repeated exposure - Category 113 14

Danger

Harmful if swallowed (H302)
Toxic if inhaled (H331)
Causes skin irritation (H315)
Causes serious eye irritation (H319)
Suspected of causing cancer (H351)
Suspected of damaging fertility or the unborn child (H361)
Causes damage to organs through prolonged or repeated exposure (H372)

Ingredient disclosure

References

• ▲1.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
• ▲2.  International Program on Chemical Safety, Environmental Health Criteria 163: Chloroform. Genève : World Health Organization. (1994). EHC163.   http://www.inchem.org/pages/ehc.html
• ▲3.  Institut national de l'environnement industriel et des risques (INERIS), Fiche de données toxicologiques et environnementales des substances chimiques. Chloroforme. (2003).   http://www.ineris.fr/ Dans Rapports d'étude, Toxicologie et environnement, Fiche de données
• ▲4.  International Program on Chemical Safety, Chloroform. Concise International Chemical Assessment . Genève : World Health Organization. (2004). CICAD 58.   http://www.inchem.org/pages/cicads.html
• ▲5.  Duprat, P., Delsaut, L. et Gradiski, D., «Pouvoir irritant des principaux solvants chlorés aliphatiques sur la peau et les muqueuses oculaires du lapin.» European Journal of Toxicology. Vol. 9, no. 3, p. 171-177. (1976). [AP-018906]
• ▲6.  International Program on Chemical Safety, Chloroforme. Concise International Chemical Assessment. Genève : World Health Organization. (2004). CICAD 58.   http://www.inchem.org/documents/cicads/cicads/cicad58.htm
• ▲7.  IARC Working group on the Evaluation of Carcinogenic Risks to Humans, Some chemicals that cause tumours of the kidney or urinary bladder in rodents and some other substances. IARC monographs on the evaluation of carcinogenic risks to humans, Vol. 73. Lyon : International Agency for Research on Cancer. (1999).   https://monographs.iarc.fr/wp-content/uploads/2018/06/mono73.pdf
• ▲8.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
• ▲9.  Schwetz, B.A., Leong, B.K.J. et Gehring, P.J., «Embryo- an fetotoxicity of inhaled chloroform in rats.» Toxicology and Applied Pharmacology. Vol. 28, p. 442-451. (1974). [AP-025828]
• ▲10.  Murray, F.J. et al., «Toxicity of inhaled chloroform in pregnant mice and their offspring.» Toxicology and Applied Pharmacology. Vol. 50, p. 515-522. (1979). [AP-025830]
• ▲11.  Agency for Toxic Substances and Disease Registry, Toxicological profile for chloroform. Atlanta, GA : ATSDR. (1997). Final report. [MO-015739]   http://www.atsdr.cdc.gov/toxprofiles/
• ▲12.  Health council of the Netherlands: Committee for compounds toxic to reproduction, «Chloroform. Evaluation of the effects on reproduction, recommendation for classification.» In: The Hague: Health Concil of the Netherlands. Vol. 07, p. 38. (2000).   http://www.gezondheidsraad.nl/en http://www.gezondheidsraad.nl/en/publications/healthy-working-conditions/nickel-and-its-compounds
• ▲13.  Yamamoto, S. et al., «Carcinogenicity and chronic toxicity in rats and mice exposed to chloroform by inhalation.» Journal of Occupational Health. Vol. 44, p. 283-293. (2002).
• ▲14.  Templin, Michael V. et al., «A 90-day chloroform inhalation study in F-344 rats: profile of toxicity and relevance to cancer studies.» Fundamental and applied toxicology. Vol. 32, p. 109-125. (1996).

The [number] refers to the Information SST database of the CNESST Documentation Center.