WHMIS (Mercuric chloride)

Workplace Hazardous Materials Information System

WHMIS 2015 classification - Note to reader

• Acute toxicity - oral - Category 21

• Skin corrosion/irritation - Category 22 3 4

• Serious eye damage/eye irritation - Category 11 3 5

• Skin sensitization - Category 16 7 8

• Germ cell mutagenicity - Category 1B3 4 9

• Reproductive toxicity - Category 24 10 11 12 13 14 15 16 17
• Toxic to the reproductive function
• Adverse effects on the development of the offspring

• Specific target organ toxicity - repeated exposure - Category 14 18 19

Danger

Fatal if swallowed (H300)
Causes skin irritation (H315)
Causes serious eye damage (H318)
May cause allergic skin reaction (H317)
May cause genetic defects (H340)
Suspected of damaging fertility or the unborn child (H361)
Causes damage to organs through prolonged or repeated exposure (H372)

Ingredient disclosure

References

• ▲1.  Joint WHO/FAO Expert Committee on Food Additives (JECFA ), «Safety evaluation of certain contaminants in food. .» In: WHO food additives series: 63. FAO JECFA monographs 8. , p. 1-799. Genève : World Health Organization ; International Programme on Chemical Safety. (2011).   http://www.inchem.org/documents/jecfa/jecmono/v63je01.pdf
• ▲2.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
• ▲3.  France. Institut national de recherche et de sécurité, Fiche toxicologique no 55 : Mercure et composés minéraux. Cahiers de notes documentaires. Paris : INRS. (1997). [RE-005509]   http://www.inrs.fr/publications/bdd/fichetox.html
  http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_55
• ▲4.  Agency for Toxic Substances and Disease Registry, Toxicological profile for mercury. Atlanta [GA] : ATSDR. (1999).   http://www.atsdr.cdc.gov/ http://www.atsdr.cdc.gov/ToxProfiles/tp46.pdf
• ▲5.  Grant, W.M. et Schuman, J.S., Toxicology of the eye : effects on the eyes and visual systems from chemicals, drugs, metals and minerals, plants, toxins and venoms; also, systemic side effects from eye medications. Vol. 2, 4éme éd. Springfield, ILL : Charles C. Thomas. (1993). [RM-515030]
• ▲6.  Rudzki, E., Rebandel, P. et Grzyma, Z., «Patch tests with occupational contactants in nurses, doctors and dentists.» Contact Dermatitis. Vol. 20, p. 247-250. (1989). [AP-026192]
• ▲7.  Nordlind, K. et Liden, S., «Patch test reactions to metal salts in patients with oral mucosal lesions associated with amalgam restorations.» Contact Dermatitis. Vol. 27, p. 157-160. (1992). [AP-039684]
• ▲8.  Crepy M.N, « Fiche d'allergologie-dermatologie professionnelle TA 90. Dermatose professionnelles allergiques aux métaux. Quatrième partie: allergie de contact aux autres métaux..» Document pour le médecin du travail . , p. 2-21. (2011).   http://www.rst-sante-travail.fr/rst/pages-article/ArticleRST.html?ref=RST.TA%2090
• ▲9.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
• ▲10.  Atkinson, A. et al., «Assessment of a two-generation reproductive and fertility study of mercuric chloride in rats.» Food and Chemical Toxicology. Vol. 39, no. 1, p. 73-84. (2001).
• ▲11.  Heath J.C. et al., «The Effects of Chronic Ingestion of Mercuric Chloride on Fertility and Testosterone Levels in Male Sprague Dawley Rats.» Journal of Biomedecine and Biotechnology. Vol. 2012, p. 1-9. (2012).   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398687/pdf/JBB2012-815186.pdf
• ▲12.  Heath J.C. et al., «The Effects of Chronic Mercuric Chloride Ingestion in Female Sprague-dawley Rats on Fertility and Reproduction.» Food and Chemical Toxicology. Vol. 47, p. 1600-1605. (2009).
• ▲13.  Zhang Y., Bolivar V.J. et Lawrence D.A., «Developmental Exposure to Mercury Chloride Does not Impair Social Behavior of C57BL/6 x BTBR F(1) Mice..» Jounal of Immunotoxicology. Vol. 9, no. 4, p. 401-10. (2012).
• ▲14.  Chehimi L. et al., «Chromic Exposure to Mercuric Chloride During Gestation Affects Sensitomotor Development and Later Behavior in Rats..» Behavioural Brain Research. Vol. 234, no. 1, p. 43-50. (2012).
• ▲15.  Huang C.F. et al., «Neurotoxicological Effects of Low Dose Methylmercury and Mercuric Chloride in Developing Offspring Mice..» Toxicology Letters. Vol. 201, no. 3, p. 196-204. (2011).
• ▲16.  Silva I.A. et al., «Prenatal HgCl2 Exposure in BALB/c Mice: Gender-Specific Effects on the Ontogeny of the Immune System..» Developmental and Comparative Immunology. Vol. 29, no. 2, p. 171-183. (2005).
• ▲17.  Zhang Y., Bolivar V.J. et Lawrence D.A., «Meternal Exposure to Mercury Chloride During Pregnancy and Lactation Affects the Immunity and Social Behavior of Offspring.» Toxicological Sciences. Vol. 133, no. 1, p. 101-111. (2013).   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693512/pdf/kft023.pdf
• ▲18.  Lauwerys, R. et al., Toxicologie industrielle et intoxications professionnelles. 5ème éd. Issy-les-Moulineaux Cedex : Elsevier Masson SAS. (2007). [RM-514015]
• ▲19.  International Program on Chemical Safety, Elemental Mercury and Inorganic Mercury Compounds: Human Health Aspects. Concise International Chemical Assessment. Genève : World Health Organization. (2003). CICAD 50.   http://www.inchem.org/documents/cicads/cicads/cicad50.htm

The [number] refers to the Information SST database of the CNESST Documentation Center.