WHMIS (Cadmium oxide)

Workplace Hazardous Materials Information System

WHMIS 2015 classification - Note to reader

• Acute toxicity - oral - Category 31 2 3 4 5 6

• Acute toxicity - inhalation - Category 22 3 4 7

• Germ cell mutagenicity - Category 24 8

• Carcinogenicity - Category 1A3 4 8 9

• Reproductive toxicity - Category 24 6 10 11 12 13 14
• Toxic to the reproductive function
• Toxic to the development

• Specific target organ toxicity - single exposure - Category 14 6 7 9

• Specific target organ toxicity - repeated exposure - Category 14 6 9 10

Danger

Toxic if swallowed (H301)
Fatal if inhaled (H330)
Suspected of causing genetic defects (H341)
May cause cancer (H350)
Suspected of damaging fertility or the unborn child (H361)
Causes damage to organs (H370)
Causes damage to organs through prolonged or repeated exposure (H372)

Ingredient disclosure

Comments: The toxicity of cadmium compounds is related to the presence of Cd2+ ion. Thus, the classification is based on the toxicity of this ion and takes account of the data available for all cadmium compounds

References

• ▲1.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
• ▲2.  National Library of Medicine, The Hazardous Substances Data Bank (HSDB). Hamilton (Ont.) : Canadian Centre for Occupational Health and Safety.   http://www.ccohs.ca/
• ▲3.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
• ▲4.  France. Institut national de recherche et de sécurité, Fiche toxicologique no 60 : Cadmium et composés minéraux. Cahiers de notes documentaires. Paris : INRS. (2022). [RE-005509]   http://www.inrs.fr/publications/bdd/fichetox.html
  http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_60
• ▲5.  IFA-Gestis, Information system on hazardous substances of the German Social Accident Insurance. Sankt Augustin, Germany : Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA).   https://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ▲6.  Bureau européen des substances chimiques, European Union Draft Risk Assessment Report : Cadmium oxide and cadmium metal. 3rd Priority List. Luxembourg : Office for Official Publications of the European Communities. (2003).   http://ecb.jrc.ec.europa.eu/esis/
  http://ecb.jrc.it//DOCUMENTS/Existing-Chemicals/RISK_ASSESSMENT/DRAFT/R303_0307_env_hh.pdf
• ▲7.  Bingham, E., Cohrssen, B. et Powell, C.H., Patty's toxicology. A Wiley-Interscience publication. New York (Toronto) : John Wiley. (2001-). [RM-214008]   http://www3.interscience.wiley.com (http://www3.interscience.wiley.com/cgi-bin/mrwhome/104554795/HOME)
• ▲8.  IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, A Review of Human Carcinogens: Arsenic, Metals, Fibres, and Dusts. IARC monographs on the evaluation of carcinogenic risks to humans, Vol. 100C. Lyon : International Agency for Research on Cancer. (2012).   http://monographs.iarc.fr/
  http://monographs.iarc.fr/ENG/Monographs/vol100C/mono100C.pdf
  
• ▲9.  IPCS (International Programme on Chemical Safety), Cadmium Oxide. ICSC#0117. IPCS, CEC. (2005).   http://www.inchem.org/documents/icsc/icsc/eics0117.htm
• ▲10.  ECHA (European Chemicals Agency) , Information on chemicals (REACH)/ECHA chemicals database. Helsinki, Finland.   http://echa.europa.eu/information-on-chemicals/registered-substances
  https://chem.echa.europa.eu/
• ▲11.  Schardein, J.L., Chemically induced birth defects. 3ème rév. & expanded. New York : Dekker. (2000). [MO-122294]
• ▲12.  Baranski, B., «Behavioral alterations in offspring of female rats repeatedly exposed to cadmium oxide by inhalation.» Toxicology Letters. Vol. 22, p. 53-61. (1984). [AP-021176]
• ▲13.  Schroeder, H.A. et Mitchener, M., «Toxic effects of trace elements on the reproduction of mice and rats.» Archives of environmental health. Vol. 23, no. 2, p. 102-106. (Aug. 1971). [AP-000933]
• ▲14.  Baranski, B, «Effect of exposure of pregnant rats to cadmium on prenatal and postnatal development of the young.» Journal of Hygiene, epidemiology, microbiology and immunology. Vol. 29, no. 3, p. 253-262. (1985). [AP-021174]

The [number] refers to the Information SST database of the CNESST Documentation Center.