WHMIS (Epichlorhydrin)

Workplace Hazardous Materials Information System

WHMIS 2015 classification - Note to reader

• Flammable liquids - Category 31
• Flash point = 37.8 °C Tag closed cup

• Acute toxicity - oral - Category 32 3

• Acute toxicity - dermal - Category 32

• Acute toxicity - inhalation - Category 24 5

• Skin corrosion/irritation - Category 12 6

• Serious eye damage/eye irritation - Category 12 4 5

• Skin sensitization - Category 1B5 7 8

• Germ cell mutagenicity - Category 24 5 9

• Carcinogenicity - Category 1B4 10 11 12

• Reproductive toxicity - Category 24 5
• Toxic to the reproductive function

• Health hazards not otherwise classified (corrosion) - Category 1

Danger

Flammable liquid and vapour (H226)
Toxic if swallowed (H301)
Toxic in contact with skin (H311)
Fatal if inhaled (H330)
Causes severe skin burns and eye damage (H314)
May cause allergic skin reaction (H317)
Suspected of causing genetic defects (H341)
May cause cancer (H350)
Suspected of damaging fertility or the unborn child (H361)
Causes severe damage to the respiratory tract

Ingredient disclosure

References

• ▲1.  United States Coast Guard et Department of Transport, Chemical Hazards Response Information System (CHRIS). Washington, D. C. : United States Coast Guard. (1999).   http://www.suttercountyfire.org/YSHMRT/CHRIS%20MANUAL%20CIM_16465_12C.pdf
• ▲2.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
• ▲3.  France. Institut national de recherche et de sécurité, Fiche toxicologique no 187 : 1-Chloro-2,3-époxypropane. Cahiers de notes documentaires. Paris : INRS. (2009). [RE-005509]   http://www.inrs.fr/publications/bdd/fichetox.html
  http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_187
• ▲4.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
• ▲5.  International Program on Chemical Safety, Environmental Health Criteria 33 : EPICHLOROHYDRIN. Genève : World Health Organization. (1984). EHC33.   http://www.inchem.org/documents/ehc/ehc/ehc33.htm
• ▲6.  ECHA (European Chemicals Agency) , Information on chemicals (REACH)/ECHA chemicals database. Helsinki, Finland.   http://echa.europa.eu/information-on-chemicals/registered-substances
  https://chem.echa.europa.eu/
• ▲7.  Rao, K. et al., «Evaluation of inhaled allyl chloride and ethyl acrylate for embryotoxic and teratogenic potential in animals.» Toxicologist. Vol. 1, p. 146-147. (1981). [AP-044204]
• ▲8.  Thorgeirsson, A. et Fregert, S., «Allergenicity of epoxy resins in the guinea pig.» Acta Dermatovener. Vol. 57, no. 3, p. 253-256. (1977). [AP-067207 ]
• ▲9.  Giri, A.K. , «Genetic toxicology of epichlorohydrin : a review .» Mutation Research. Vol. 386, no. 1, p. 25-38 . (1997). [AP-053340 ]
• ▲10.  IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Overall evaluations of carcinogenicity : an updating of IARC monographs volumes 1-42. IARC monographs on the evaluation of carcinogenic risks to humans, Supplement 7. Lyon : International Agency for Research on Cancer. (1987).   https://monographs.iarc.fr/wp-content/uploads/2018/06/Suppl7.pdf
  http://monographs.iarc.fr/
• ▲11.  IARC Working Group on the Evaluation of Carcinogenic Risks of Chemical to Man, Cadmium, nickel, some epoxides, miscellaneous industrial chemicals and general considerations on volatile anaesthetics. IARC monographs on the evaluation of carcinogenic risks of chemical to man, Vol. 11. Lyon : International Agency for Research on Cancer. (1976).   https://monographs.iarc.fr/wp-content/uploads/2018/06/mono11.pdf
  http://www.iarc.fr
• ▲12.  IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide : part 2. IARC monographs on the evaluation of carcinogenic risks to humans, Vol. 71. Lyon : International Agency for Research on Cancer. (1999).   https://monographs.iarc.fr/wp-content/uploads/2018/06/mono71.pdf

The [number] refers to the Information SST database of the CNESST Documentation Center.