WHMIS (Lithium nitrite)

Workplace Hazardous Materials Information System

WHMIS 2015 classification - Note to reader

• Oxidizing solids - Category 21

• Reproductive toxicity - Category 1A2 3 4 5 6 7
• Toxic to the development

• Specific target organ toxicity - repeated exposure - Category 13 8 9

Danger

May intensify fire; oxidizer (H272)
May damage fertility or the unborn child (risk of fetal cardiac malformations) (H360)
Causes damage to organs (central nervous system) through prolonged or repeated exposure (H372)

Ingredient disclosure

Comments: Due to the lack of data, classifications regarding reproductive toxicity (H360) and specific target organ toxicity - repeated exposure (H372) were established by analogy to lithium carbonate.

References

• ▲1.  Canada. Ministère des transports, Règlement sur le transport des marchandises dangereuses. Ottawa : Éditions du gouvernement du Canada. (2014). [RJ-410222]   http://www.tc.gc.ca/fra/tmd/clair-menu-497.htm
  http://www.tc.gc.ca/tmd/menu.htm
• ▲2.  Moore, J.A., «An assessment of lithium using the iehr evaluative process for assessing human developmental and reproductive toxicity of agents.» Reproductive Toxicology. Vol. 9, no. 2, p. 175-210. (1995). [AP-046801 ]
• ▲3.  NIOSH, Health hazard evaluation report, Lithium corporation of America. Bessemer City, North Carolina. (1981). HHE 80-036-922.
• ▲4.  Poels, E.M.P. et al., «Lithium during pregnancy and after delivery: a review.» International journal of bipolar disorders. Vol. 6, no. 26. (2018).   https://journalbipolardisorders.springeropen.com/articles/10.1186/s40345-018-0135-7
• ▲5.  Munk-Olsen, T. et al., «Maternal and infant outcomes associated with lithium use in pregnancy:.» Lancet psychiatry. Vol. 5, no. 8, p. 644-652. (2018).   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077091/pdf/nihms-977891.pdf
• ▲6.  Patorno, E. et al., «Lithium Use in Pregnancy and the Risk of Cardiac Malformations.» The new england journal of medecine. Vol. 376, no. 23, p. 2245-2254. (2017).   https://www.nejm.org/doi/full/10.1056/NEJMoa1612222
• ▲7.  Diav-Citrin, O. et al., «Pregnancy Outcome Following in Utero Exposure to Lithium: A Prospective, Comparative, Observational Study .» The american journal of psychiatry. Vol. 171, no. 7, p. 785-794. (2014).   https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.2014.12111402?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
• ▲8.  ECHA (European Chemicals Agency) , Information on chemicals (REACH)/ECHA chemicals database. Helsinki, Finland.   http://echa.europa.eu/information-on-chemicals/registered-substances
  https://chem.echa.europa.eu/
• ▲9.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html

The [number] refers to the Information SST database of the CNESST Documentation Center.