WHMIS (Nickel sulfate hexahydrate)

Workplace Hazardous Materials Information System

WHMIS 2015 classification - Note to reader

• Acute toxicity - oral - Category 31 2 3

• Respiratory sensitization - Category 14 5

• Skin sensitization - Category 16

• Carcinogenicity - Category 1A7

• Reproductive toxicity - Category 1B8 9 10 11 12 13
• Toxic to the development (Category 1B)
• Toxic to the reproductive function (Category 2)

• Specific target organ toxicity - repeated exposure - Category 111

Danger

Toxic if swallowed (H301)
May cause allergy or asthma symptoms or breathing difficulties if inhaled (H334)
May cause allergic skin reaction (H317)
May cause cancer (H350)
May damage fertility or the unborn child (H360)
Causes damage to organs through prolonged or repeated exposure (H372)

Ingredient disclosure

References

• ▲1.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
• ▲2.  Mastromatteo, Ernest , «Nickel .» American Industrial Hygiene Association Journal. Vol. 47, no. 10, p. 589-601. (1986).
• ▲3.  Henderson, R.G. et al., «Acute oral toxicity of nickel compounds.» Regulatory toxicology and pharmacology. Vol. 62, p. 425-432. (2012).
• ▲4.  Bernstein, I.L. et al., Asthma in the workplace : and related conditions. 3 éd. New York : Taylor & Francis. (2006).   www.taylorandfrancis.com
• ▲5.  Deutsche Forschungsgemeinschaft (DFG), Nickel and its compounds (in the form of inhalable dusts/aerosols). The MAK Collection for Occupational Health and Safety, Vol. 22. Allemagne : Wiley-VCH Verlag GmbH & Co. KGaA. (2006).   http://onlinelibrary.wiley.com/book/10.1002/3527600418
  http://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb744002vere0022/abstract
• ▲6.  Rietschel, R.L. et Fowler, Jr., J.F., Fisher's contact dermatitis. 5ème. Philadelphia : Lippincott Williams & Wilkins. (2001).
• ▲7.  IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, A Review of Human Carcinogens: Arsenic, Metals, Fibres, and Dusts. IARC monographs on the evaluation of carcinogenic risks to humans, Vol. 100C. Lyon : International Agency for Research on Cancer. (2012).   http://monographs.iarc.fr/
  http://monographs.iarc.fr/ENG/Monographs/vol100C/mono100C.pdf
  
• ▲8.  Patty, F.A., Harris, R.L. et Ayer, H.E., Patty's industrial hygiene. A Wiley-Interscience publication, 5th ed. New York ; Toronto : John Wiley & Sons. (2000). [RM-214007]
• ▲9.  Smith, M.K. et al., «Perinatal toxicity associated with nickel chloride exposure.» Environmental Research. Vol. 61(2), p. 200-211. (1993).
• ▲10.  Käkelä, R., Käkelä, A. et Hyvärinen, H., «Effects of nickel chloride on reproduction of the rat and possible antagonistic role of selenium.» Comparative biochemistry and physiology. Part C, Pharmacology, toxicology and endocrinology. Vol. 123(1), p. 27-37. (1999).
• ▲11.  Agency for Toxic Substances and Diseases Registry (ATSDR), Toxicological profile for nickel. ATSDR. Washington D.C. : US Department of Health and Human Services. (2005).   http://www.atsdr.cdc.gov/toxprofiles/index.asp
  https://www.atsdr.cdc.gov/ToxProfiles/tp15.pdf
• ▲12.  Ambrose, A.M. et al., «Long term toxicologic assessment of nickel in rats and dogs.» Journal of food science and technology. Vol. 13, p. 181-187. (1976). [AP-037169]
• ▲13.  Health council of the Netherlands: Committee for compounds toxic to reproduction, «Nickel and its compounds. Evaluation of the effects on reproduction, recommendation for classification.» In: The Hague: Health Concil of the Netherlands. Vol. 05, p. 77. (2003).   http://www.gezondheidsraad.nl/en https://www.gezondheidsraad.nl/en/task-and-procedure/areas-of-activity/healthy-working-conditions/nickel-and-its-compounds

The [number] refers to the Information SST database of the CNESST Documentation Center.