WHMIS (Dicyclohexylmethane 4,4'-diisocyanate)

Workplace Hazardous Materials Information System

WHMIS 2015 classification - Note to reader

• Acute toxicity - inhalation - Category 21 2 3

• Skin corrosion/irritation - Category 21 2 4 5

• Serious eye damage/eye irritation - Category 21 2 4 5

• Respiratory sensitization - Category 12

• Skin sensitization - Category 12 4

• Specific target organ toxicity - single exposure (respiratory tract irritation) - Category 3 - Respiratory tract irritation

Danger

Fatal if inhaled (H330)
Causes skin irritation (H315)
Causes serious eye irritation (H319)
May cause allergy or asthma symptoms or breathing difficulties if inhaled (H334)
May cause allergic skin reaction (H317)
May cause respiratory irritation (H335)

Ingredient disclosure

Comments: Due to the lack of data, classifications regarding respiratory sensitization (H334) and respiratory irritation (H335) were established by analogy to diisocyanates.

References

• ▲1.  ECHA (European Chemicals Agency) , Information on chemicals (REACH)/ECHA chemicals database. Helsinki, Finland.   http://echa.europa.eu/information-on-chemicals/registered-substances
  https://chem.echa.europa.eu/
• ▲2.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
• ▲3.  Pauluhn J., Desmodur W, Acute Inhalation Toxicity in the Rat According to OECD Guideline No. 403. (1995). 8EHQ-0499-14423.
• ▲4.  OECD, «SIDS Initial Assessment Report for SIAM 20. 4,4'-Methylenedicyclohexyl Diisocyanate.» In: OECD Screening Information Data Set (SIDS) . Paris : UNEP Publications. (2005).   http://www.alipa.org/uploads/Modules/Publications/OECD%20SIDS%20H12MDI.pdf
• ▲5.  Toxicological Investigation of 1,1'-Methylenebis(4-isocyanatocyclohexane) With Cover Letter Dated 072987. (1987). Microfiche : OTS0515454

The [number] refers to the Information SST database of the CNESST Documentation Center.