WHMIS (Tri-o-cresyl phosphate)

Workplace Hazardous Materials Information System

WHMIS 2015 classification - Note to reader

• Acute toxicity - oral - Category 41 2 3

• Reproductive toxicity - Category 24 5 6 7
• Toxic to the reproductive function

• Specific target organ toxicity - single exposure - Category 11 4 5 8

• Specific target organ toxicity - repeated exposure - Category 14 9

Danger

Harmful if swallowed (H302)
Suspected of damaging fertility or the unborn child (H361)
Causes damage to organs (H370)
Causes damage to organs through prolonged or repeated exposure (H372)

Ingredient disclosure

References

• ▲1.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
• ▲2.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
• ▲3.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
• ▲4.  Bingham, E., Cohrssen, B. et Powell, C.H., Patty's toxicology. A Wiley-Interscience publication. New York (Toronto) : John Wiley. (2001-). [RM-214008]   http://www3.interscience.wiley.com (http://www3.interscience.wiley.com/cgi-bin/mrwhome/104554795/HOME)
• ▲5.  International Program on Chemical Safety, Environmental Health Criteria 110: Tricresyl Phosphate. Genève : World Health Organization. (1990). EHC110. [MO-016056]   http://www.inchem.org/documents/ehc/ehc/ehc110.htm
• ▲6.  Somkuti S.G. et al., «Time Course of the Tri-o-cresul Phosphate-Induced Testicular Lesions in F-344 Rats: Enzymatic, Hormonal, and Sperm Parameter Studies..» Toxicology and Applied Pharmacology. Vol. 89, no. 1, p. 64-72. (1987).
• ▲7.  Somkuti S.G. et al., «Reproductive Tract Lesions Resulting from Subchronic Administration (63 days) of Tri-c-cresyl Phosphate in Male Rats..» Toxicology and Applied Pharmacology. Vol. 89, no. 1, p. 49-63. (1987).
• ▲8.  Gosselin, R.E., Hodge, H.C. et Smith, R.P., Clinical toxicology of commercial products. 5e éd. Baltimore (MD) : Williams & Wilkins. (1984). [RM-514002]
• ▲9.  Veronesi, B., «A rodent model of organophosphorus-induced delayed neuropathy : distribution of central (spinal cord) and peripheral nerve damage.» Neuropathology and applied neurobiology. Vol. 10, no. 5, p. 357-368. (Sept.-Oct. 1984). [AP-000918]

The [number] refers to the Information SST database of the CNESST Documentation Center.