WHMIS (Maleic anhydride)

Workplace Hazardous Materials Information System

WHMIS 2015 classification - Note to reader

• Combustible dusts - See comments below1 2 3

• Acute toxicity - oral - Category 44 5 6

• Skin corrosion/irritation - Category 15 6 7

• Serious eye damage/eye irritation - Category 16 8

• Respiratory sensitization - Category 1A6 9 10 11 12

• Skin sensitization - Category 1A6 13 14 15

• Health hazards not otherwise classified (corrosion) - Category 1

Danger

Harmful if swallowed (H302)
Causes severe skin burns and eye damage (H314)
May cause allergy or asthma symptoms or breathing difficulties if inhaled (H334)
May cause allergic skin reaction (H317)
Causes severe damage to the respiratory tract

Ingredient disclosure

Comments: This product could belong to the hazard class "Combustible dust", based on various factors related to the combustibility and explosiveness of its dust, including composition, shape and size of the particles.

References

• ▲1.  Vincoli, J.W., Risk management for hazardous chemicals : G-Z. Vol. 2. Boca Raton : Lewis Publishers. (1997). [RM-515112]
• ▲2.  IFA-Gestis, Information system on hazardous substances of the German Social Accident Insurance. Sankt Augustin, Germany : Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA).   https://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ▲3.  National Fire Protection Association, Fire protection guide to hazardous materials. 14th ed. Quincy, Mass. : NFPA. (2010). [RR-334001]
• ▲4.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
• ▲5.  ECHA (European Chemicals Agency) , Information on chemicals (REACH)/ECHA chemicals database. Helsinki, Finland.   http://echa.europa.eu/information-on-chemicals/registered-substances
  https://chem.echa.europa.eu/
• ▲6.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
• ▲7.  Institut national de recherche et de sécurité, Fiche toxicologique n° 205 : Anhydride maléique. Cahiers de notes documentaires. Paris, France : INRS. (2004). [RE-005509]   http://www.inrs.fr/publications/bdd/fichetox.html
  http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_205
• ▲8.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
• ▲9.  Topping, M.D. et al., «Specificity of the human IgE response to inhaled acid anhydrides.» Journal of Allergy and Clinical Immunology. Vol. 77, no. 6, p. 834-842. (1986). [AP-021035]
• ▲10.  Baur, X. et al., «A clinical and immunological study on 92 workers occupationally exposed to anhydrides.» International Archives of Occupational and Environmental Health. Vol. 67, no. 6, p. 395-403. (1995). [AP-048750]
• ▲11.  Venables, K.M., «Low molecular weight chemicals, hypersensitivity, and direct toxicity: the acid anhydrides.» British Journal of Industrial Medicine. Vol. 46, p. 222-232. (1989). [AP-025649]
• ▲12.  Graneek, B.J. et al., «Occupational asthma caused by maleic anhydride bronchial provocation testing and immunological data.» Thorax. Vol. 41, no. 3, p. 251. (1986). [AP-018977]
• ▲13.  Welinder, H. et al., «Strucutre-activity relationships of organic acid anhydrides as antigens in an animal model.» Toxicology. Vol. 103, no. 2, p. 127-136. (1995). [AP-041996]
• ▲14.  Nakamura, Y. et al., «A quantitative comparison of induction and challenge concentrations inducing a 50% positive response in three skin sensitization tests : the guinea pig maximization test, adjuvant and patch test and Buehler test.» Journal of Toxicological Sciences. Vol. 24, no. 2, p. 123-131. (1999). [AP-061273]
• ▲15.  Stevens, M.A., «Use of the albino guinea-pig to detect the skin-sensitizing ability of chemicals.» British Journal of Industrial Medicine. Vol. 24, p. 189-202. (1967). [AP-024848]   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1008581/pdf/brjindmed00119-0021.pdf

The [number] refers to the Information SST database of the CNESST Documentation Center.