WHMIS (Chromium trioxide)

Workplace Hazardous Materials Information System

WHMIS 2015 classification - Note to reader

• Oxidizing solids - Undefined category1
• This hazard class has been assigned according to the information obtained from the consulted scientific literature, but it does not allow to specify the hazard category.

• Acute toxicity - oral - Category 22 3 4

• Acute toxicity - dermal - Category 22 5

• Acute toxicity - inhalation - Category 22 3 4

• Skin corrosion/irritation - Category 12 3 5 6
• Strong acid: pH of a 1% solution = 1,1

• Serious eye damage/eye irritation - Category 12 3 5 6

• Respiratory sensitization - Category 16 7 8 9

• Skin sensitization - Category 1A4 6 10 11

• Germ cell mutagenicity - Category 23 4 6 12 13 14 15

• Carcinogenicity - Category 1A3 16 17

• Reproductive toxicity - Category 1B4 6 14 18 19 20
• Toxic to the development (Category 1B)
• Toxic to the reproductive function (Category 2)

• Health hazards not otherwise classified (corrosion) - Category 1

Danger

Oxidizing Solids : Undefined hazard statement
Fatal if swallowed (H300)
Fatal in contact with skin (H310)
Fatal if inhaled (H330)
Causes severe skin burns and eye damage (H314)
May cause allergy or asthma symptoms or breathing difficulties if inhaled (H334)
May cause allergic skin reaction (H317)
Suspected of causing genetic defects (H341)
May cause cancer (H350)
May damage fertility or the unborn child (H360)
Causes severe damage to the respiratory tract

Ingredient disclosure

Comments: This classification is based on all available data for all water-soluble hexavalent chromium (Cr VI) as potassium dichromate.

References

• ▲1.  Canada. Ministère des transports, Règlement sur le transport des marchandises dangereuses. Ottawa : Éditions du gouvernement du Canada. (2014). [RJ-410222]   http://www.tc.gc.ca/fra/tmd/clair-menu-497.htm
  http://www.tc.gc.ca/tmd/menu.htm
• ▲2.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
• ▲3.  France. Institut national de recherche et de sécurité, Fiche toxicologique no 1 : Trioxyde de chrome. Cahiers de notes documentaires. Paris : INRS. (2009). [RE-005509]   http://www.inrs.fr/publications/bdd/fichetox.html
  http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_1
• ▲4.  Agency for Toxic Substances and Disease Registry, Toxicological profile for chromium. Atlanta, GA : ATSDR. (2000). Microfiche : PB93-182434, ATSDR/TP-92/08   http://www.atsdr.cdc.gov/toxprofiles/
• ▲5.  ECHA (European Chemicals Agency) , Information on chemicals (REACH)/ECHA chemicals database. Helsinki, Finland.   http://echa.europa.eu/information-on-chemicals/registered-substances
  https://chem.echa.europa.eu/
• ▲6.  Bureau européen des substances chimiques, European Union Risk Assessment Report : Chromium trioxide, sodium chromate, sodium dichromate, ammonium dichromate and potassium dichromate. 3rd Priority List, Vol. 53. Luxembourg : Office for Official Publications of the European Communities. (2005). EUR 21508 EN.   http://echa.europa.eu/documents/10162/3be377f2-cb05-455f-b620-af3cbe2d570b
• ▲7.  Criteria group for occupational standards, «Scientific basis for Swedish occupational standards XXI. Consensus report for chromium and chromium compounds.» Arbete och Hälsa. Vol. VI, no. 22, p. 18-40. (2000). [AP-063399]   https://gupea.ub.gu.se/dspace/handle/2077/3194?locale=en
  http://www.inchem.org/documents/kemi/kemi/ah2000_22.pdf
• ▲8.  Asthmagen? : critical assessments of the evidence for agents implicated in occupational asthma. Health and Safety Executive. Sudbury, Suffolk, G.B. : HSE Books. (2001). [MO-020018]   http://www.hse.gov.uk/asthma/asthmagen.pdf
• ▲9.  Bernstein, I.L. et al., Asthma in the workplace : and related conditions. 3 éd. New York : Taylor & Francis. (2006).   www.taylorandfrancis.com
• ▲10.  Lauwerys, R. et al., Toxicologie industrielle et intoxications professionnelles. 5ème éd. Issy-les-Moulineaux Cedex : Elsevier Masson SAS. (2007). [RM-514015]
• ▲11.  Nethercott, J. et al., «A study of chromium induced allergic contact dermatitis with 54 volunteers: Implications for environmental risk assessment..» Occupational and Environmental Medicine. Vol. 51, p. 371-380. (1994).
• ▲12.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
• ▲13.  De Flora, S. et al., «Genotoxicity of chromium compounds: a review.» Mutation research. Vol. 238, no. 2. (1990). [AP-028592]
• ▲14.  International Program on Chemical Safety, Environmental Health Criteria 61: Chromium. Genève : World Health Organization. (1988). EHC61.  

  http://www.inchem.org/pages/ehc.html

  https://www.inchem.org/documents/ehc/ehc/ehc61.htm

  
  
• ▲15.  Sarkar, D. , Sharma, A. et Talukder, G. , «Differential protection of chlorophyllin against clastogenic effects of chromium and chlordane in mouse bone marrow in vivo.» Mutation Research. Vol. 301, p. 33-38. (1993). [AP-046830]
• ▲16.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
• ▲17.  IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, A Review of Human Carcinogens: Arsenic, Metals, Fibres, and Dusts. IARC monographs on the evaluation of carcinogenic risks to humans, Vol. 100C. Lyon : International Agency for Research on Cancer. (2012).   http://monographs.iarc.fr/
  http://monographs.iarc.fr/ENG/Monographs/vol100C/mono100C.pdf
  
• ▲18.  France. Institut national de recherche et de sécurité, Fiche toxicologique no 180 : Chromates et dichromates de sodium et potassium. Cahiers de notes documentaires. Paris : INRS. (2009). [RE-005509]   http://www.inrs.fr/publications/bdd/fichetox.html
  http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_180
• ▲19.  Li, H., Chen, Q. et Li, S., «Effect of Cr(VI) exposure on sperm quality: human and animal studies..» Annals of Occupational Hygiene. Vol. 45, no. 7, p. 505-511. (2001).
• ▲20.  The health council of the Netherlands, Chromium VI and its compounds: Evaluation of the effects on reproduction, recommendation for classification. The Hague. (2001).   https://www.gezondheidsraad.nl/sites/default/files/0101osh.pdf
  http://www.gezondheidsraad.nl/en/publications/healthy-working-conditions

The [number] refers to the Information SST database of the CNESST Documentation Center.