WHMIS (Aniline hydrochloride)

Workplace Hazardous Materials Information System

WHMIS 2015 classification - Note to reader

• Acute toxicity - oral - Category 41 2

• Serious eye damage/eye irritation - Category 2A

• Skin sensitization - Category 13

• Germ cell mutagenicity - Category 24 5 6 7

• Carcinogenicity - Category 1B

• Specific target organ toxicity - single exposure - Category 13 4 5 8

• Specific target organ toxicity - repeated exposure - Category 29 10

Danger

Harmful if swallowed (H302)
Causes serious eye irritation (H319)
May cause allergic skin reaction (H317)
Suspected of causing genetic defects (H341)
May cause cancer (H350)
Causes damage to organs (H370)
May cause damage to organs through prolonged or repeated exposure (H373)

Ingredient disclosure

Comments: Due to the lack of data, classification regarding eye irritation (H319) and skin sensitization (H317) were established by analogy to aniline.

References

• ▲1.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
• ▲2.  IFA-Gestis, Information system on hazardous substances of the German Social Accident Insurance. Sankt Augustin, Germany : Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA).   https://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ▲3.  Bureau européen des substances chimiques, European Union Risk Assessment Report : Aniline. 1st Priority List, Vol. 50. Allemagne : Office for Official Publications of the European Communities. (2004).   http://ecb.jrc.ec.europa.eu/esis/ Rechercher le CAS et sélectionner "Final RAR -View and save it" dans le bas de la page.
• ▲4.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
• ▲5.  George, E., Andrews, M. et Westmoreland, C., «Effects of azobenzene and aniline in the rodent bone marrow micronucleus test.» Carcinogenesis. Vol. 11, no. 9, p. 1551-1556. (Sept. 1990). [AP-001030]
• ▲6.  Bomhard, E.M., «High-dose clastogenic activity of aniline in the rat bone marrow and its relationship to the carcinogenicity in the spleen of rats.» Archives of toxicology. Vol. 77, no. 5, p. 291-297. (May 2003). [AP-001031]
• ▲7.  Witt, K.L., Knapton, A. et Wehr, C. M., «Micronucleated erythrocyte frequency in peripheral blood of B6C3F1 mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program..» Environmental and Molecular Mutagenesis. Vol. 36, p. 163-194. (2000).
• ▲8.  Khan, M.F. et al., «Acute hematopoietic toxicity of aniline in rats.» Toxicology letters. Vol. 92, no. 1, p. 31-37. (June 1997). [AP-001033]
• ▲9.  PRICE, C.J. et al., «TERATOLOGIC AND POSTNATAL EVALUATION OF ANILINE HYDROCHLORIDE IN THE FISCHER 344 RATS .» Toxicology and Applied Pharmacology. Vol. 77, p. 465-478. (1985). [AP-034108]
• ▲10.  Khan, M.F. et al., «Subchronic toxicity of aniline hydrochloride in rats.» Archives of environmental contamination and toxicology. Vol. 24, no. 3, p. 368-374. (Apr. 1993). [AP-001034]

The [number] refers to the Information SST database of the CNESST Documentation Center.