WHMIS (Nickel dioxide)

Workplace Hazardous Materials Information System

WHMIS 2015 classification - Note to reader

• Skin sensitization - Category 11

• Carcinogenicity - Category 1A2 3 4

• Specific target organ toxicity - repeated exposure - Category 15 6

Danger

May cause allergic skin reaction (H317)
May cause cancer (H350)
Causes damage to organs through prolonged or repeated exposure (H372)

Ingredient disclosure

Comments: Due to the lack of data, classifications regarding skin sensitization (H317) and specific organ toxicity - repeated exposure (H373) were established by analogy to nickel monoxide.

References

• ▲1.  Deutsche Forschungsgemeinschaft (DFG), Nickel and its compounds (in the form of inhalable dusts/aerosols). The MAK Collection for Occupational Health and Safety, Vol. 22. Allemagne : Wiley-VCH Verlag GmbH & Co. KGaA. (2006).   http://onlinelibrary.wiley.com/book/10.1002/3527600418
  http://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb744002vere0022/abstract
• ▲2.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
• ▲3.  IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Chromium, nickel and welding. IARC monographs on the evaluation of carcinogenic risks to humans, Vol. 49. Lyon : International Agency for Research on Cancer. (1990).   https://monographs.iarc.fr/wp-content/uploads/2018/06/mono49.pdf
  http://www.iarc.fr
• ▲4.  IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, A Review of Human Carcinogens: Arsenic, Metals, Fibres, and Dusts. IARC monographs on the evaluation of carcinogenic risks to humans, Vol. 100C. Lyon : International Agency for Research on Cancer. (2012).   http://monographs.iarc.fr/
  http://monographs.iarc.fr/ENG/Monographs/vol100C/mono100C.pdf
  
• ▲5.  France. Institut national de recherche et de sécurité, Fiche toxicologique no 68 : Nickel et ses oxydes. Cahiers de notes documentaires. Paris : INRS. (2009). [RE-005509]   http://www.inrs.fr/publications/bdd/fichetox.html
  http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_68
• ▲6.  Agency for Toxic Substances and Disease Registry, Toxicological profile for nickel. Atlanta, GA : ATSDR. (1988). Microfiche : PB89-160378, ATSDR/TP-88/19  

  https://wwwn.cdc.gov/TSP/ToxProfiles/ToxProfiles.aspx?id=245&tid=44

  https://www.atsdr.cdc.gov/ToxProfiles/tp15.pdf

The [number] refers to the Information SST database of the CNESST Documentation Center.