WHMIS (Warfarin)

Workplace Hazardous Materials Information System

WHMIS 2015 classification - Note to reader

• Acute toxicity - oral - Category 21 2 3 4 5 6

• Reproductive toxicity - Category 1A1 3 7 8
• Toxic to the development

• Specific target organ toxicity - repeated exposure - Category 11 3

Danger

Fatal if swallowed (H300)
May damage fertility or the unborn child (H360)
Causes damage to organs through prolonged or repeated exposure (H372)

Ingredient disclosure

References

• ▲1.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
• ▲2.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
• ▲3.  France. Institut national de recherche et de sécurité, Fiche toxicologique no 216 : Warfarine (Coumafène). Cahiers de notes documentaires. Paris : INRS. (2010). [RE-005509]   http://www.inrs.fr/publications/bdd/fichetox.html
  http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_216
• ▲4.  CIRCABC - Europa, Directive 98/8EC Concerning the Placing of Biocidal Products on the Market. Inclusion of Active Substances in Annex I or IA Directive 98/8/EC. Warfatin. Product type 14 (Rodenticides). (2009).   https://circabc.europa.eu/sd/a/5bcfe8f9-228c-4bff-a347-556018a9af30/2009-09-16%20BPD%20Warfarin%20AR.pdf
• ▲5.  Back, N., Steger, R. et Glassman, J.M., «Comparative acute oral toxicity of sodium warfarin and microcrystalline warfarin in the Sprague-Dawley rat.» Pharmacological research communications. Vol. 10, no. 5, p. 445-452. (May 1978). [AP-001019]
• ▲6.  Bai, K.M., Krishnakumari, M.K. et Majumder, S.K., «Single dose toxicity (oral) of a chronic anticoagulant rodenticide-warfarin in albino rats.» Comparative physiology and ecology. Vol. 17, no. 2, p. 75-82. (1992). [AP-001020]
• ▲7.  Schardein, J.L., Chemically induced birth defects. 3ème rév. & expanded. New York : Dekker. (2000). [MO-122294]
• ▲8.  Briggs, G.G., Freeman, R.K. et Yaffe, S.J., Drugs in pregnancy and lactation : a reference guide to fetal and neonatal risk. 10e éd.. Philadelphie, Penns. : Wolters Kluwer. (2015).

The [number] refers to the Information SST database of the CNESST Documentation Center.