Anhydride phtalique

Numéro CAS : 85-44-9

  • Fiche complète
  • PMSD
  • SIMDUT
  • Résumé

Identification

Description


Numéro UN : UN2214

Formule moléculaire brute : C8H4O3

Principaux synonymes

Noms français :

  • 1,3-ISOBENZOFURANDIONE
  • Anhydride phtalique
  • ANHYDRIDE PHTALIQUE SOLIDE
  • ANHYDRIDE PHTALIQUE, SOLIDE

Noms anglais :

  • PHTHALANDIONE
  • PHTHALIC ACID ANHYDRIDE
  • Phthalic anhydride
Utilisation et sources d'émission 1 2 3

L'anhydride phtalique est utilisé notamment dans :

  • la production de plastifiants
  • la fabrication de teintures ou d'indicateurs colorés, par exemple la phénolphtaléine
  • des résines en tant qu'agent de durcissement
  • la synthèse de produits pharmaceutiques
  • la production de fongicides

Références

  • ▲1.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
  • ▲1.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
  • ▲1.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
  • ▲1.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
  • ▲2.  Lewis, R.J., Sr., Hawley's condensed chemical dictionary. 14th ed. New York : John Wiley & Sons. (2001).   http://onlinelibrary.wiley.com/book/10.1002/9780470114735
  • ▲3.  O'Neil, M.J. et al., The Merck Index : an encyclopedia of chemicals, drugs, & biologicals. 15e éd. Cambridge, G.-B. : Royal Society of Chemistry. (2013). [RM-403001]   https://www.rsc.org/Merck-Index/
  • ▲3.  O'Neil, M.J. et al., The Merck Index : an encyclopedia of chemicals, drugs, & biologicals. 15e éd. Cambridge, G.-B. : Royal Society of Chemistry. (2013). [RM-403001]   https://www.rsc.org/Merck-Index/
  • ▲4.  Cairelli, S.G., Ludwig, H.R. et Whalen, J.J., Documentation for immediately dangerous to life or health concentrations (IDLHS). Cincinnati (OH) : NIOSH. (1994). PB-94-195047. [RM-515102]   http://www.cdc.gov/niosh/idlh/intridl4.html
  • ▲5.  Vincoli, J.W., Risk management for hazardous chemicals : G-Z. Vol. 2. Boca Raton : Lewis Publishers. (1997). [RM-515112]
  • ▲6.  Kroschwitz, J.I., Kirk-Othmer encyclopedia of chemical technology. 5th ed. Hoboken, N.J. : John Wiley & Sons. (2004-). [RT-423004]
  • ▲7.  Pohanish, R.P. et Greene, S.A., Hazardous materials handbook. New York (NY) : Van Nostrand Reinhold. (1996). [RR-515125]
  • ▲8.  Drolet, D. et Beauchamp, G, Guide d'échantillonnage des contaminants de l'air en milieu de travail. Études et recherches / Guide technique, 8ème éd. revue et mise à jour. Montréal : IRSST. (2012). T-06. [MO-220007]   http://www.irsst.qc.ca
    https://www.irsst.qc.ca/publications-et-outils/publication/i/384/n/guide-d-echantillonnage-des-contaminants-de-l-air-en-milieu-de-travail
  • ▲9.  Règlement sur la santé et la sécurité du travail [S-2.1, r. 13]. Québec : Éditeur officiel du Québec. [RJ-510071]   http://legisquebec.gouv.qc.ca/fr/ShowDoc/cr/S-2.1,%20r.%2013
  • ▲11.  ECHA (European Chemicals Agency) , Information on chemicals (REACH)/ECHA chemicals database. Helsinki, Finland.   http://echa.europa.eu/information-on-chemicals/registered-substances
    https://chem.echa.europa.eu/
  • ▲11.  ECHA (European Chemicals Agency) , Information on chemicals (REACH)/ECHA chemicals database. Helsinki, Finland.   http://echa.europa.eu/information-on-chemicals/registered-substances
    https://chem.echa.europa.eu/
  • ▲12.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
  • ▲13.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
  • ▲13.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
  • ▲14.  Topping, M.D. et al., «Specificity of the human IgE response to inhaled acid anhydrides.» Journal of Allergy and Clinical Immunology. Vol. 77, no. 6, p. 834-842. (1986). [AP-021035]
  • ▲15.  IFA-Gestis, Information system on hazardous substances of the German Social Accident Insurance. Sankt Augustin, Germany : Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA).   https://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ▲16.  The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals et The Dutch Expert Commitee on Occupational Standards, 136. Cyclic Acid Anhydrides. Arbete och Hälsa , Vol. NR 2004:15. Stockholm (Suède) : Arbetslivsinstitutet. (2004).   http://www.inchem.org/documents/kemi/kemi/ah2004_15.pdf
  • ▲17.  National Industrial Chemicals Notification & Assessment Scheme, 1,3-Isobenzofurandione : Human health tier II assessment.. Inventory multi-tiered assessment and prioritisation (IMAP). Sydney, Australie : NICNAS. (2013).  

    1,3-Isobenzofurandione_Human health tier II assessment.pdf (industrialchemicals.gov.au)


  • ▲18.  France. Institut national de recherche et de sécurité, Fiche toxicologique no 38 : Anhydride phtalique. Cahiers de notes documentaires. Paris : INRS. (2016). [RE-005509]   http://www.inrs.fr/publications/bdd/fichetox.html
    http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_38
  • ▲18.  France. Institut national de recherche et de sécurité, Fiche toxicologique no 38 : Anhydride phtalique. Cahiers de notes documentaires. Paris : INRS. (2016). [RE-005509]   http://www.inrs.fr/publications/bdd/fichetox.html
    http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_38
  • ▲19.  Grant, W.M. et Schuman, J.S., Toxicology of the eye : effects on the eyes and visual systems from chemicals, drugs, metals and minerals, plants, toxins and venoms; also, systemic side effects from eye medications. Vol. 2, 4éme éd. Springfield, ILL : Charles C. Thomas. (1993). [RM-515030]
  • ▲19.  Grant, W.M. et Schuman, J.S., Toxicology of the eye : effects on the eyes and visual systems from chemicals, drugs, metals and minerals, plants, toxins and venoms; also, systemic side effects from eye medications. Vol. 2, 4éme éd. Springfield, ILL : Charles C. Thomas. (1993). [RM-515030]
  • ▲20.  OECD, «SIDS Initial Assessment Report For SIAM 20 - Phthalic Anhydre CAS No: 85-44-9.» In: OECD Screening Information Data Set (SIDS) . Paris : UNEP Publications. (2005).   http://www.inchem.org/documents/sids/sids/85449.pdf
  • ▲21.  Ward, M.J. et Davies, D., «Asthma due to grinding epoxy resin cured with phthalic anhydride.» Clinical Allergy. Vol. 12, p. 165-168. (1982). [AP-001585]
  • ▲22.  Levy, S.A., Storey, J. et Phashko, B.E., «Meat worker's asthma.» Journal of Occupational Medicine. Vol. 20, no. 2, p. 116-117. (1978).
  • ▲23.  Pauli, G. et al., «Meat wrapper's asthma: identification of the causal agent.» Clinical Allergy. Vol. 10, p. 263-269. (1980). [AP-044462]
  • ▲24.  Nielsen, J. et al., «Serum IgE and lung function in workers exposed to phthalic anhydride.» International Archives of Occupational and Environmental Health. Vol. 63, no. 3, p. 199-204. (1991). [AP-037738 ]
  • ▲25.  Bernstein, D.I., Patterson, R. et Zeiss, C.R., «Clinical and immunologic evaluation of trimellitic anhydride and phthalic anhydride exposed workers using a questionnaire with comparative analysis of enzyme-linked immunosorbent and radioimmunoassay studies.» Journal of Allergy and Clinical Immunology. Vol. 69, no. 3, p. 311-318. (1982). [AP-022699]
  • ▲26.  Basketter, D.A. et Scholes, E.W., «Comparison of the local lymph node assay with the guinea-pig maximization test for the detection of a range of contact allergens.» Food and Chemical Toxicology. Vol. 30, no. 1, p. 65-69. (1992).
  • ▲27.  van Tongeren, M.J.A. et al., «Exposure to acid anhydrides in three resin and one cushioned flooring manufacturing plants.» Annals of Occupational Hygiene. Vol. 39, no. 5, p. 559-571. (1995). [AP-048889]
  • ▲28.  Rosenberg, N., Rousselin, X. et Gervais, P., «Fiche d'allergologie respiratoire no. 10. Allergie respiratoire professionnelle aux anhydrides d'acide.» Documents pour le Médecin du Travail. Vol. 35, p. 271-276. (1988). [AP-023601]   http://www.dmt-prevention.fr/
  • ▲29.  Nordman, H. et al., «Specific IgE and IgG4 antibodies in respiratory allergy caused by phthalic anhydride.» Chest. Vol. 91, no. 2, p. 296. (1987).
  • ▲30.  Kimber, I. et al., «The local lymph node assay : developments and applications.» Toxicology. Vol. 93, no. 1, p. 13-31. (1994). [AP-063496]
  • ▲31.  Stevens, M.A., «Use of the albino guinea-pig to detect the skin-sensitizing ability of chemicals.» British Journal of Industrial Medicine. Vol. 24, p. 189-202. (1967). [AP-024848]   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1008581/pdf/brjindmed00119-0021.pdf
  • ▲32.  Ashby, J. et al., «Structure activity relationship in skin sensitization using the murine local lymph node assay.» Toxicology. Vol. 103, no. 3, p. 177-194. (1995). [AP-048616]
  • ▲33.  Wernfors, M. et al., «Phthalic anhydride-induced occupational asthma.» International Archives of Allergy and Applied Immunology. Vol. 79, p. 77-82. (1986). [AP-012224]
  • ▲34.  Fawcett, I.W., Taylor, A.J.N. et Pepys, J., «Asthma due to inhaled chemical agents - epoxy resin systems containing phthalic acid anhydride, trimellitic acid anhydride and triethylene tetramine.» Clinical Allergy. Vol. 7, no. 7, p. 1-14. (1977). [AP-055294]
  • ▲35.  Maccia, C.A. et al., «In vitro demonstration of specific IgE in phthalic anhydride hypersensitivity.» American Review of Respiratory Disease. Vol. 113, no. 5, p. 701-704. (1976). [AP-044461 ]
  • ▲36.  Tarvainen, K. et al., «Immunologic contact urticaria due to airborne methylhexahydrophthalic and methyltetrahydrophthalic anhydrides.» Contact Dermatitis. Vol. 32, p. 204-209. (1995). [AP-022685]
  • ▲37.  Chester, E.H. et al., «Phthalic anhydride asthma.» Clinical Allergy. Vol. 7, p. 15-20. (1977). [AP-038019]
  • ▲38.  Murine local lymph node assay: a test method for assessing the allergenic contact dermatitis potential of chemical compounds. (1999). Microfiche : PB2001-104492, NIH-PUB-99-4494
  • ▲39.  Kimber, I., Hilton, J. et Weisenberger, C., «The murine local lymph node assay for identification of contact allergens : a preliminary evaluation of in situ measurement of lymphocyte proliferation.» Contact Dermatits. Vol. 21, p. 215-220. (1989).
  • ▲40.  American Conference of Governmental Industrial Hygienists, «Phthalic Anhydride.» In: Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. Cincinnati, Ohio : ACGIH. (2017). Publication #0100Doc.   http://www.acgih.org
  • ▲41.  Barker, R.D. et al., «Risk factors for sensitisation and respiratory symptoms among workers exposed to acid anhydrides : a cohort study.» Occupational and Environmental Medicine. Vol. 55, no. 10, p. 684-691. (1998).   (PDF) Risk factors for sensitisation and respiratory symptoms among workers exposed to acid anhydrides: A cohort study (researchgate.net)
  • ▲42.  Zeiss, C.R. et al., «Cross-reactivity of IgG antibody to reactive anhydrides.» Clinical research. Vol. 36, no. 6, p. 861A. (1988). [AP-061812 ]
  • ▲43.  Hatanaka, S. et al., «The characteristics of specific IgG to phthalic anhydride(PA)-albumin conjugate.» Industrial Health. Vol. 35, no. 4, p. 508-514. (1997).
  • ▲44.  Combustion and explosion characteristics of dusts : BIA-Report 13/97. Sankt Ausgustin, Allemagne. (1997). [MO-127954]
  • ▲45.  National Fire Protection Association, NFPA 499 : Recommended Practice for the Classification of Combustible Dusts and of Hazardous (classified) Locations for Electrical Installations in Chemical Process Areas. 2013. Massachusetts : An International Codes and Standards Organization. (2013).   http://www.nfpa.org
  • ▲46.  Canada. Ministère des transports, Règlement sur le transport des marchandises dangereuses. Ottawa : Éditions du gouvernement du Canada. (2014). [RJ-410222]   http://www.tc.gc.ca/fra/tmd/clair-menu-497.htm
    http://www.tc.gc.ca/tmd/menu.htm

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